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Bovine Respiratory Disease (BRD) is a complex disease with many contributing factors—including stress that compromises the immune system. Even though there are many antimicrobial options for BRD, veterinarians and producers continue to look for new technology to treat BRD. Zelnate DNA Immunostimulant is a novel, non-antibiotic technology that enhances the animal’s natural defenses against BRD. Zelnate is the first licensed immunostimulant that aids in the treatment of BRD associated with Mannheimia haemolytica.